A double-blind, randomized, placebo-controlled pilot trial of atorvastatin for nephrogenic diabetes insipidus in lithium users.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Lithium remains an important treatment for mood disorders but is associated with kidney disease. Nephrogenic diabetes insipidus (NDI) is associated with up to 3-fold risk of incident chronic kidney disease among lithium users. There are limited randomized controlled trials (RCT) for treatments of lithium-induced NDI, and existing therapies can be poorly tolerated. Therefore, novel treatments are needed for lithium-induced NDI.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Bipolar Disord

Title: Bipolar disorders

Publisher: Wiley

ISSN (Electronic): 1399-5618

ISSN (Print): 1398-5647

Publication date (Electronic): Feb 2021

Volume: 23

Issue: 1

Affiliations

[1 ] Geri-PARTy Research Group, Jewish General Hospital, Montreal, QC, Canada.

[2 ] Douglas Mental Health University Institute, Montreal, QC, Canada.

[3 ] Division of Nephrology, University of Naples, Naples, Italy.

[4 ] Department of Epidemiology, Biostatistics and Occupational Health, McGill University Health Centre, Montreal, QC, Canada.

[5 ] Division of Nephrology, University Health Network, University of Toronto (UofT), Toronto, ON, Canada.

[6 ] Biogem S.c.a.r.l., Istituto di Ricerche Genetiche "Gaetano Salvatore", Ariano Irpino, Italy.

[7 ] Department of Psychiatry, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

[8 ] Department of Psychiatry, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.

[9 ] Amsterdam UMC, Department of Psychiatry, GGZinGeest, Neuroscience, Amsterdam, The Netherlands.

[10 ] Department of Psychiatry, McGill University Health Centre, Montreal, QC, Canada.

[11 ] Department of Biomedicine, University of Aarhus, Aarhus, Denmark.

Article

DOI: 10.1111/bdi.12973

PubMed ID: 32621644

SO-VID: 774e1053-a91f-40c5-b072-deed4d9a5ba1

History

Keywords: lithium use,nephrogenic diabetes insipidus,bipolar disorder,kidney function

Data availability:

Keywords: lithium use, nephrogenic diabetes insipidus, bipolar disorder, kidney function

A double-blind, randomized, placebo-controlled pilot trial of atorvastatin for nephrogenic diabetes insipidus in lithium users.

Read this article at

Abstract

Related collections

Herbal Medicines Journal (Herb Med J)

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 146

Cited by 5