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      Association of Elevations of Specific T Cell and Monocyte Subpopulations in Rheumatoid Arthritis With Subclinical Coronary Artery Atherosclerosis.

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          Abstract

          Coronary artery disease (CAD) is the leading cause of excess deaths in rheumatoid arthritis (RA). However, identification of features denoting patients with a risk of developing CAD is lacking. The composition of circulating peripheral blood mononuclear cell (PBMC) subsets in RA patients differs markedly from that in healthy controls with regard to the extent of T cell activation, with clonal expansion and differentiation to effector memory status, and presence of inflammatory monocytes. In this study, we sought to evaluate whether elevations in these PBMC subpopulations in RA patients could denote those with an increased risk of subclinical CAD, as determined by the presence of coronary artery calcification (CAC).

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          Author and article information

          Journal
          Arthritis & rheumatology (Hoboken, N.J.)
          Wiley
          2326-5205
          2326-5191
          Jan 2016
          : 68
          : 1
          Affiliations
          [1 ] Columbia University College of Physicians and Surgeons, New York, New York.
          Article
          NIHMS720156
          10.1002/art.39419
          4690807
          26360530

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