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      Hemodialysis with Two Sequential Hemodialyzers

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          Background/Aims: The principal aims of the new hemodialysis methods are: a short-time dialysis session, the increase of solute removal, the patient’s well-being and, when possible, the reduction of global costs. Other researchers have experimented the simultaneous use of two hemodialyzers in hemodialysis. We tested a new technique which involves the use of two Cuprophan hemodialyzers in sequence (double filter system: DFS), each one connected separately to fresh dialysate. Methods: We treated 15 large patients with DFS and compared the results with conventional hemodialysis (CHD). Results: Our results showed a significant difference between CHD and DFS in the depuration values. After the first hemodialyzer, modification of pH and electrolytes occurred in the plasma composition. In the second hemodialyzer, urea depuration occured without further significant changes in hydroelectrolytic and acid-basic plasma patterns. The Kt/V increased from 1.10 to 1.29 (18%). Conclusion: Our technique is conceived for the following goal: to increase the diffusion of solution without increasing costs and side effects.

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          Author and article information

          Am J Nephrol
          American Journal of Nephrology
          S. Karger AG
          December 2000
          22 December 2000
          : 20
          : 6
          : 429-436
          aDepartment of Nephrology, ‘Tor Vergata University’ Rome; bDepartment of Nephrology and Dialysis, Aurelia Hospital, Rome and cChemical Laboratory, Aurelia Hospital, Rome, Italy
          46195 Am J Nephrol 2000;20:429–436
          © 2000 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 9, Tables: 3, References: 14, Pages: 8
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