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      Growth Hormone (GH) Status and Body Composition in Normal Ageing and in Elderly Adults with GH Deficiency

      Hormone Research in Paediatrics

      S. Karger AG

      Growth hormone, Growth hormone deficiency, Body composition, Elderly adults, Ageing

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          Abstract

          Similarities have been observed between the changes associated with ageing and the symptoms of growth hormone (GH) deficiency. Changes such as increased fat mass and decreased muscle mass occur both in GH-deficient patients and in otherwise healthy elderly individuals. Moreover, ageing is associated with decreasing GH and insulin-like growth factor I (IGF-I) levels. It has been suggested, therefore, that hypothalamic-pituitary disease leading to GH deficiency (GHD) in elderly patients would have less impact than in younger adults. Studies suggest that healthy elderly individuals have normal pituitary reserves of GH, but that spontaneous GH secretion falls by around 14% per decade of adult life, leading to a state of functional GH insufficiency. Despite this, elderly patients with GHD experience reductions in GH secretion and IGF-I levels, compared with controls, which are of similar magnitude to those seen in younger GH-deficient adults. The metabolic changes associated with GHD are also seen in elderly patients compared with healthy elderly controls. Fat mass, particularly in the abdominal region, is significantly increased, with a strong correlation between fat mass and body mass index. Markers of bone formation and resorption are significantly reduced in the GH-deficient patients. Elderly adults who have hypothalamic-pituitary disease have a degree of GHD that can be distinguished from the decline in GH and IGF-I levels that is seen with normal ageing. GHD in elderly patients leads to significant changes in body composition and bone. Thus, these patients are likely to benefit from GH replacement therapy.

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          Most cited references 10

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                Author and article information

                Journal
                HRE
                Horm Res Paediatr
                10.1159/issn.1663-2818
                Hormone Research in Paediatrics
                S. Karger AG
                978-3-8055-7609-3
                978-3-318-00998-9
                1663-2818
                1663-2826
                2003
                July 2003
                17 November 2004
                : 60
                : Suppl 1
                : 105-111
                Affiliations
                University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
                Article
                71234 Horm Res 2003;60(suppl 1):105–111
                10.1159/000071234
                12955026
                © 2003 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 3, Tables: 2, References: 23, Pages: 7
                Categories
                Somatopause and Elderly GHD – Similarities and Differences

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