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Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
Karen H Lu
1 ,
Andrea P Patterson ,
Lin Wang ,
Rebecca T Marquez ,
Edward N Atkinson ,
Keith A Baggerly ,
Lance R Ramoth ,
Daniel G Rosen ,
Jinsong Liu ,
Ingegerd Hellstrom ,
David Smith ,
Lynn Hartmann ,
David Fishman ,
Andrew Berchuck ,
Rosemarie Schmandt ,
Regina Whitaker ,
David M Gershenson ,
Gordon B Mills ,
Robert C Bast
May 15 2004
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Abstract
Advanced-stage epithelial ovarian cancer has a poor prognosis with long-term survival in less than 30% of patients. When the disease is detected in stage I, more than 90% of patients can be cured by conventional therapy. Screening for early-stage disease with individual serum tumor markers, such as CA125, is limited by the fact that no single marker is up-regulated and shed in adequate amounts by all ovarian cancers. Consequently, use of multiple markers in combination might detect a larger fraction of early-stage ovarian cancers.