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      What are we doing in the dermatology outpatient department amidst the raging of the 2019 novel coronavirus?

      editorial
      , MD, , PhD, MD, , PhD, MD
      Journal of the American Academy of Dermatology
      by the American Academy of Dermatology, Inc.

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          Abstract

          In late December 2019, several individuals with unexplained pneumonia were reported in Wuhan, China. A novel coronavirus was subsequently identified as the causative pathogen and provisionally designated 2019 novel coronavirus (2019-nCoV). 1 As of February 10, 2020, 42,638 cases of 2019-nCoV infection have been confirmed in China, with 21,675 suspected cases and 1016 deaths. There are still more than 3000 confirmed cases every day, involving people living in or visiting Wuhan, as a subsequent characteristic of human-to-human transmission. 2019-nCoV continues to spread around the world and has been reported in other countries such as the United States. 2 Hospitals in all provinces and cities across China have taken effective measures to control the spread of 2019-nCoV. On January 24, 2020, the West China Hospital of Sichuan University temporarily shut the doors of its dermatology outpatient department and dermatology surgery by postponing all of the elective operations and limiting to only emergency operations. We did not, however, completely halt the services to some patients who need to visit the dermatology outpatient department during the 2019-nCoV outbreak. At the same time, to meet the medical requirements and reduce the flow of patients to the skin clinic, we began free online and telephone consultation by providing free dermatology consultations. The dermatology outpatient department in West China Hospital was scheduled to run on January 28, 2020, mainly for critical care patients. Patients who had made an advanced appointment for obtaining medical service but chose not to visit received a full refund of registration fees. The number of dermatology outpatient clinics has been drastically reduced from 8 to 4, and only 1 accompanying person is allowed to enter the clinic. People entering the outpatient and inpatient buildings must wear masks and have their body temperature monitored by professionals wearing tight protective clothing. At the entrance of the building, anyone with a fever (body temperature ≥37.3°C), travel history to Wuhan in last 2 weeks, clear contact with residents in Wuhan in last 2 weeks, or contact with people with a fever would be directly sent to the fever clinic for screening. These individuals are considered to have been exposed and are quarantined for 2 weeks, and potential exposures are also asked to quarantine themselves for 2 weeks at home. During the skin clinic, patients are not allowed to take off their masks except on indications of facial lesions. Doctors must wear masks, surgical caps, protective suits, gloves, and goggles at work; they take off their protective equipment only after their work in a designated disposable area. In other respects, educational programs and activities of West China Hospital have come to a halt; graduate students and interns are prohibited from returning to school and work. Also, West China Hospital established special psychologic intervention counseling via a telephone and network platform to help those in need and published a psychologic protection handbook for free download. It is uncertain to predict when the 2019-nCoV will end at the time of this writing. The West China hospital is still playing a powerful role in defending against the epidemic outbreak and is a microcosm of all of the countless Chinese hospitals at this moment.

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          Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

          Summary Background In late December, 2019, patients presenting with viral pneumonia due to an unidentified microbial agent were reported in Wuhan, China. A novel coronavirus was subsequently identified as the causative pathogen, provisionally named 2019 novel coronavirus (2019-nCoV). As of Jan 26, 2020, more than 2000 cases of 2019-nCoV infection have been confirmed, most of which involved people living in or visiting Wuhan, and human-to-human transmission has been confirmed. Methods We did next-generation sequencing of samples from bronchoalveolar lavage fluid and cultured isolates from nine inpatients, eight of whom had visited the Huanan seafood market in Wuhan. Complete and partial 2019-nCoV genome sequences were obtained from these individuals. Viral contigs were connected using Sanger sequencing to obtain the full-length genomes, with the terminal regions determined by rapid amplification of cDNA ends. Phylogenetic analysis of these 2019-nCoV genomes and those of other coronaviruses was used to determine the evolutionary history of the virus and help infer its likely origin. Homology modelling was done to explore the likely receptor-binding properties of the virus. Findings The ten genome sequences of 2019-nCoV obtained from the nine patients were extremely similar, exhibiting more than 99·98% sequence identity. Notably, 2019-nCoV was closely related (with 88% identity) to two bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21, collected in 2018 in Zhoushan, eastern China, but were more distant from SARS-CoV (about 79%) and MERS-CoV (about 50%). Phylogenetic analysis revealed that 2019-nCoV fell within the subgenus Sarbecovirus of the genus Betacoronavirus, with a relatively long branch length to its closest relatives bat-SL-CoVZC45 and bat-SL-CoVZXC21, and was genetically distinct from SARS-CoV. Notably, homology modelling revealed that 2019-nCoV had a similar receptor-binding domain structure to that of SARS-CoV, despite amino acid variation at some key residues. Interpretation 2019-nCoV is sufficiently divergent from SARS-CoV to be considered a new human-infecting betacoronavirus. Although our phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans. Importantly, structural analysis suggests that 2019-nCoV might be able to bind to the angiotensin-converting enzyme 2 receptor in humans. The future evolution, adaptation, and spread of this virus warrant urgent investigation. Funding National Key Research and Development Program of China, National Major Project for Control and Prevention of Infectious Disease in China, Chinese Academy of Sciences, Shandong First Medical University.
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            First Case of 2019 Novel Coronavirus in the United States

            Summary An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. We report the first case of 2019-nCoV infection confirmed in the United States and describe the identification, diagnosis, clinical course, and management of the case, including the patient’s initial mild symptoms at presentation with progression to pneumonia on day 9 of illness. This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection.
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              Author and article information

              Contributors
              Journal
              J Am Acad Dermatol
              J. Am. Acad. Dermatol
              Journal of the American Academy of Dermatology
              by the American Academy of Dermatology, Inc.
              0190-9622
              1097-6787
              17 February 2020
              April 2020
              17 February 2020
              : 82
              : 4
              : 1034
              Affiliations
              [1]Department of Dermatology, West China Hospital of Sichuan University
              Author notes
              []Correspondence to: Siliang Xue, PhD, MD, 37# Guoxuexiang, Chengdu 610041, China. xuesiliang@ 123456163.com
              Article
              S0190-9622(20)30268-1
              10.1016/j.jaad.2020.02.030
              7134506
              32081700
              7783298b-c0d2-4d70-b17b-d209d5095073
              © 2020 by the American Academy of Dermatology, Inc.

              Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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