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      High-throughput telomere length quantification by FISH and its application to human population studies.

      Proceedings of the National Academy of Sciences of the United States of America

      ultrastructure, Telomere, Sex Factors, genetics, Neoplasms, Middle Aged, Mice, Male, methods, In Situ Hybridization, Fluorescence, Humans, HeLa Cells, Genetics, Population, Female, Animals, Aged, 80 and over, Aged, Age Factors

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          Abstract

          A major limitation of studies of the relevance of telomere length to cancer and age-related diseases in human populations and to the development of telomere-based therapies has been the lack of suitable high-throughput (HT) assays to measure telomere length. We have developed an automated HT quantitative telomere FISH platform, HT quantitative FISH (Q-FISH), which allows the quantification of telomere length as well as percentage of short telomeres in large human sample sets. We show here that this technique provides the accuracy and sensitivity to uncover associations between telomere length and human disease.

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          Author and article information

          Journal
          10.1073/pnas.0609367104
          1828130
          17369361

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