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      Efficacy of the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470) on osteosarcoma growth and lung metastasis in rats.

      Japanese Journal of Clinical Oncology
      Animals, Antibiotics, Antineoplastic, administration & dosage, therapeutic use, Cyclohexanes, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Injections, Subcutaneous, Lung Neoplasms, prevention & control, secondary, Male, Osteosarcoma, drug therapy, Rats, Rats, Inbred F344, Sesquiterpenes, Tumor Cells, Cultured

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          Abstract

          The efficacy of the anti-angiogenic agent, O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470), against primary tumor growth and spontaneous lung metastasis was evaluated experimentally using a transplantable osteosarcoma line in rats previously established in our laboratory. Male Fischer 344 rats bearing the tumor with a high potential for metastasis received intermittent or continuous subcutaneous administrations of AGM-1470. Both treatment regimens resulted in significant inhibitions of spontaneous lung metastasis and primary tumor growth in a dose-dependent manner, with continuous administration of AGM-1470 exerting the most pronounced inhibitory effects on both parameters.

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