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      Genomic medicine and developing countries: creating a room of their own

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          Abstract

          The authors explore large-scale population genotyping projects in Mexico, India and Thailand to demonstrate that developing countries can harness human genetic variation to benefit their populations — by adopting these resources to improve public health and create knowledge-based economies.

          Abstract

          The notion that developing countries must wait for the developed world to make advances in science and technology that they later import at great cost is being challenged. We have previously argued that developing countries can harness human genetic variation to benefit their populations and economies. Based on our empirical studies of large-scale population genotyping projects in Mexico, India and Thailand, we describe how these resources are being adopted to improve public health and create knowledge-based economies. A significant additional benefit is building the capacity for scientific research and internalizing advances in technology, whatever their source.

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          Most cited references30

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          Characterization of a novel coronavirus associated with severe acute respiratory syndrome.

          P Rota (2003)
          In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            A vision for the future of genomics research.

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni.

              Schistosoma mansoni is the primary causative agent of schistosomiasis, which affects 200 million individuals in 74 countries. We generated 163,000 expressed-sequence tags (ESTs) from normalized cDNA libraries from six selected developmental stages of the parasite, resulting in 31,000 assembled sequences and 92% sampling of an estimated 14,000 gene complement. By analyzing automated Gene Ontology assignments, we provide a detailed view of important S. mansoni biological systems, including characterization of metazoa-specific and eukarya-conserved genes. Phylogenetic analysis suggests an early divergence from other metazoa. The data set provides insights into the molecular mechanisms of tissue organization, development, signaling, sexual dimorphism, host interactions and immune evasion and identifies novel proteins to be investigated as vaccine candidates and potential drug targets.
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                Author and article information

                Contributors
                a.daar@utoronto.ca
                Journal
                Nat Rev Genet
                Nat. Rev. Genet
                Nature Reviews. Genetics
                Nature Publishing Group UK (London )
                1471-0056
                1471-0064
                2008
                : 9
                : 6
                : 487-493
                Affiliations
                [1 ]Béatrice Séguin, Billie-Jo Hardy, Peter A. Singer and Abdallah S. Daar are at the McLaughlin–Rotman Centre for Global Health, Program on Life Sciences, Ethics and Policy, University Health Network/McLaughlin Centre for Molecular Medicine at University of Toronto, MaRS Centre, South Tower, Suite 406, 101 College Street, Toronto, Ontario M5G 1L7, Canada., ,
                [2 ]GRID grid.17063.33, ISNI 0000 0001 2157 2938, Béatrice Séguin is also at the Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario M5S 3M2, Canada., ; ,
                [3 ]GRID grid.17063.33, ISNI 0000 0001 2157 2938, Billie-Jo Hardy, Peter A. Singer and Abdallah S. Daar are also at the Faculty of Medicine, Medical Sciences Building, 1 King's College Circle, University of Toronto, Toronto, Ontario M5S 1A8, Canada., ; ,
                Article
                BFnrg2379
                10.1038/nrg2379
                7096950
                18487990
                7792405b-e918-47cb-91a7-9bc06328ab65
                © Nature Publishing Group 2008

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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                © Springer Nature Limited 2008

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