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Epstein-Barr virus latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovirus HERV-K18 superantigen.

Author(s): German Calderon-Cardenas, Manuel Huber, Gang Chen, Natalie Sutkowski

Publication date: 2004-06-30

Keywords: Animals, Cell Line, Endogenous Retroviruses, genetics, metabolism, Gene Expression Regulation, Viral, Herpesvirus 4, Human, Humans, Superantigens, Transcriptional Activation, Viral Envelope Proteins, Viral Matrix Proteins, Virus Latency

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Abstract

Superantigens are microbial proteins that strongly stimulate T cells. We described previously that the Epstein-Barr virus (EBV) transactivates a superantigen encoded by the human endogenous retrovirus, HERV-K18. We now report that the transactivation is dependent upon the EBV latent cycle proteins. Moreover, LMP-2A is sufficient for induction of HERV-K18 superantigen activity.

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PubMed ID:: 15220463

PMC ID:: 434102

DOI:: 10.1128/JVI.78.14.7852-7860.2004

ScienceOpen disciplines: Chemistry

Keywords: Animals,Cell Line,Endogenous Retroviruses,genetics,metabolism,Gene Expression Regulation, Viral,Herpesvirus 4, Human,Humans,Superantigens,Transcriptional Activation,Viral Envelope Proteins,Viral Matrix Proteins,Virus Latency

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ScienceOpen disciplines: Chemistry

Epstein-Barr virus latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovirus HERV-K18 superantigen.

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Journal of Circulating Biomarkers

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