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      Is the Sympathetic Nervous System Altered in Children with Familial History of Arterial Hypertension?

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          Abstract

          The sympathetic nervous system has been investigated in 42 children with family history of arterial hypertension and 68 children of the same age without hypertensive relatives. Pressure responses to mental arithmetic and to isometric handgrip stress were measured in both groups, along with 24 h catecholamine excretion. Resting blood pressure and heart rate did not show any difference between groups. The increase in diastolic pressure during the mental arithmetic exercise was, however, significantly greater in children with family history of hypertension. A sharp increase in blood pressure and heart rate was observed during isometric handgrip in both groups without any significant difference. Twenty-four hour catecholamine urinary excretion was significantly higher in the group with family history of hypertension (31 ± 15 vs. 23 ± 13 µg/24 h; p < 0.05). These results seem to indicate that an initial impairment of the sympathetic activity is already detectable in young offspring of hypertensive patients.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1988
          1988
          11 November 2008
          : 75
          : 3
          : 200-205
          Affiliations
          aInstitute of Internal Medicine and Metabolic Diseases, Clinica Medica, and bInstitute of Clinical and Experimental Pharmacology, 2nd Medical School, University of Naples, Italy
          Article
          174371 Cardiology 1988;75:200–205
          10.1159/000174371
          3416329
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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