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      Comparison of phosphodiesterase 10A, dopamine receptors D1 and D2 and dopamine transporter ligand binding in the striatum of the R6/2 and BACHD mouse models of Huntington's disease.

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          Abstract

          Phosphodiesterase 10A (PDE10A) is expressed at high levels in the striatum and has been proposed both as a biomarker for Huntington's disease pathology and as a target for intervention.

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          Author and article information

          Journal
          J Huntingtons Dis
          Journal of Huntington's disease
          IOS Press
          1879-6397
          1879-6397
          2014
          : 3
          : 4
          Affiliations
          [1 ] Department of Neuroscience, Amgen Inc., Thousand Oaks, CA, USA.
          [2 ] UCI Memory Impairments and Neurological Disorders Institute, CA, USA.
          [3 ] South San Francisco, CA, USA.
          [4 ] UCI Memory Impairments and Neurological Disorders Institute, CA, USA Departments of Neurobiology and Behavior, and Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
          Article
          BR8820K473634655
          10.3233/JHD-140129
          25575954
          77ad063d-c09c-47ec-bd11-9f9a67ac40fd
          History

          mouse model,dopamine transporter,dopamine receptor,degeneration,Phosphodiesterase 10A,Basal Ganglia,radioligand assay

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