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      Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line.

      Inflammation Research

      Calcimycin, pharmacology, Carcinogens, Cell Line, Cytokines, metabolism, Enzyme Activation, drug effects, Humans, Interleukin-1beta, Interleukin-6, Interleukin-8, Ionophores, Mast Cells, cytology, NF-kappa B, Quercetin, Tetradecanoylphorbol Acetate, Tumor Necrosis Factor-alpha, p38 Mitogen-Activated Protein Kinases

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          Abstract

          Mast cell-mediated allergic inflammation is involved in many diseases such as asthma, sinusitis, and rheumatoid arthritis. Mast cells induce production of pro-inflammatory cytokines with immune regulatory properties. We investigated the effect of quercetin on the expression of pro-inflammatory cytokines in human mast cell line, HMC-1. HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 (PMACI). Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells. Quercetin attenuated PMACI-induced activation of NF-kappaB and p38 mitogen-activated protein kinase. Our study provides evidence that quercetin may suitable for the treatment of mast cell-derived allergic inflammatory diseases.

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          Author and article information

          Journal
          17588137
          10.1007/s00011-007-6172-9

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