Hyaluronic acid and phospholipid interactions useful for repaired articular cartilage surfaces—a mini review toward tribological surgical adjuvants

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Abstract

This mini review is focused on the emerging nexus between the medical device and pharmaceutical industries toward the treatment of damaged articular cartilage. The physical rationale of hyaluronic acid and phospholipid preparations as tribological surgical adjuvants for repaired articular cartilage surfaces is explored, with directions for possible new research which have arisen due to the therapeutic advance of the physiochemical scalpel. Because synovial joint lubrication regimes become dysfunctional at articular cartilage lesion sites as a result of the regional absence of the surface active phospholipid layer and its inability to reform without surgical repair, hyaluronic acid and phospholipid intra-articular injections have yielded inconsistent efficacy outcomes and only short-term therapeutic benefits mostly due to non-tribological effects. Parameters for hydrophobic-polar type interactions as applied to the lubricating properties of normal and osteoarthritic synovial fluid useful for repaired articular cartilage surfaces are discussed.

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Viscosupplementation for Osteoarthritis of the Knee: A Systematic Review of the Evidence.

David Jevsevar, Patrick Donnelly, Gregory Brown … (2015)

The purpose of this analysis was to determine the clinical significance of injectable hyaluronic acid (HA) in the treatment of knee osteoarthritis, and to assess which trial-level factors influence the overall treatment effect of HA on pain (as measured by a VAS [visual analog scale] or the WOMAC [Western Ontario and McMaster Universities Osteoarthritis Index]) and the WOMAC function and WOMAC stiffness subscales.

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Articular Joint Lubricants during Osteoarthritis and Rheumatoid Arthritis Display Altered Levels and Molecular Species

Marta Krystyna Kosinska, Taryn E. Ludwig, Gerhard Liebisch … (2015)

Background Hyaluronic acid (HA), lubricin, and phospholipid species (PLs) contribute independently or together to the boundary lubrication of articular joints that is provided by synovial fluid (SF). Our study is the first reporting quantitative data about the molecular weight (MW) forms of HA, lubricin, and PLs in SF from cohorts of healthy donors, patients with early (eOA)- or late (lOA)-stage osteoarthritis (OA), and patients with active rheumatoid arthritis (RA). Methods We used human SF from unaffected controls, eOA, lOA, and RA. HA and lubricin levels were measured by enzyme-linked immunosorbent assay. PLs was quantified by electrospray ionization tandem mass spectrometry. Fatty acids (FAs) were analyzed by gas chromatography, coupled with mass spectrometry. The MW distribution of HA was determined by agarose gel electrophoresis. Results Compared with control SF, the concentrations of HA and lubricin were lower in OA and RA SF, whereas those of PLs were higher in OA and RA SF. Moreover, the MW distribution of HA shifted toward the lower ranges in OA and RA SF. We noted distinct alterations between cohorts in the relative distribution of PLs and the degree of FA saturation and chain lengths of FAs. Conclusions The levels, composition, and MW distribution of all currently known lubricants in SF—HA, lubricin, PLs—vary with joint disease and stage of OA. Our study is the first delivering a comprehensive view about all joint lubricants during health and widespread joint diseases. Thus, we provide the framework to develop new optimal compounded lubricants to reduce joint destruction.

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Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials.

Ti Wang, Leng Chang, Sheng Hou … (2004)

The magnitude of the therapeutic effects of intra-articular injection of hyaluronic acid on osteoarthritis of the knee is still in question. The aim of this meta-analysis was to elucidate the therapeutic efficacy and safety of intra-articular injection of hyaluronic acid for osteoarthritis of the knee. We conducted a meta-analysis of twenty blinded randomized controlled trials that compared the therapeutic effect of intra-articular injection of hyaluronic acid with that of intra-articular injection of a placebo to treat osteoarthritis of the knee. The outcome end points were classified into three categories: pain with activities, pain without activities, and function. The outcome measures of the efficacy of hyaluronic acid were the mean differences in the efficacy scores between the hyaluronic acid and placebo groups. The outcome measure of the safety of hyaluronic acid was the relative risk of adverse events. Intra-articular injection of hyaluronic acid can decrease symptoms of osteoarthritis of the knee. We found significant improvements in pain and functional outcomes with few adverse events. However, there was significant between-study heterogeneity in the estimates of the efficacy of hyaluronic acid. Subgroup analysis and meta-regression analysis showed that lower methodological quality such as a single-blind or single-center design resulted in higher estimates of hyaluronic acid efficacy, that introduction of acetaminophen as an escape analgesic in the trial resulted in lower estimates of hyaluronic acid efficacy, and that patients older than sixty-five years of age and those with the most advanced radiographic stage of osteoarthritis (complete loss of the joint space) were less likely to benefit from intra-articular injection of hyaluronic acid. This meta-analysis confirmed the therapeutic efficacy and safety of intra-articular injection of hyaluronic acid for the treatment of osteoarthritis of the knee. Additional well-designed randomized controlled trials with high methodological quality are needed to resolve the continued uncertainty about the therapeutic effects of different types of hyaluronic acid products on osteoarthritis of the knee in various clinical situations and patient populations. Therapeutic study, Level II-3b (systematic review; nonhomogeneous Level-I studies). See Instructions to Authors for a complete description of levels of evidence.

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Author and article information

Contributors

Stanislaw Jung: +48 601664852 , jungstanislaw@gmail.com

Journal

Journal ID (nlm-ta): Colloid Polym Sci

Journal ID (iso-abbrev): Colloid Polym Sci

Title: Colloid and Polymer Science

Publisher: Springer Berlin Heidelberg (Berlin/Heidelberg )

ISSN (Print): 0303-402X

Publication date (Electronic): 13 February 2017

Publication date PMC-release: 13 February 2017

Publication date (Print): 2017

Volume: 295

Issue: 3

Pages: 403-412

Affiliations

[1 ]Institute of Mechanical Engineering, University of Science and Technology, Bydgoszcz, PL Poland

[2 ]ISNI 0000 0004 0620 6106, GRID grid.25588.32, Institute of Chemistry, , University in Bialystok, ; Bialystok, PL Poland

[3 ]Institute of Mathematics and Physics, University of Science and Technology, Bydgoszcz, PL Poland

[4 ]Department of Research and Development, NuOrtho Surgical, Inc., Boston, MA USA

[5 ]ISNI 0000 0000 9548 4925, GRID grid.254989.b, Department of Biology, , Delaware State University, ; Dover, USA

[6 ]Biovico sp z.o.o, Gdynia, PL Poland

Article

Publisher ID: 4014

DOI: 10.1007/s00396-017-4014-z

PMC ID: 5321697

SO-VID: 77fca84d-d07c-4a0c-b7d0-5fb1ba87ae27

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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

History

Date received : 1 September 2016

Date revision received : 2 January 2017

Date accepted : 5 January 2017

Funding

Funded by: University of Technology and Life Science

Award ID: BS 39/2014

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ScienceOpen disciplines: Polymer chemistry

Keywords: hydrogels,micelles,amphiphiles,biomedical applications,colloids,nanocomposites

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ScienceOpen disciplines: Polymer chemistry

Keywords: hydrogels, micelles, amphiphiles, biomedical applications, colloids, nanocomposites

Hyaluronic acid and phospholipid interactions useful for repaired articular cartilage surfaces—a mini review toward tribological surgical adjuvants

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Abstract

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Electrospinning for biomedical applications

Most cited references 26

Viscosupplementation for Osteoarthritis of the Knee: A Systematic Review of the Evidence.

Articular Joint Lubricants during Osteoarthritis and Rheumatoid Arthritis Display Altered Levels and Molecular Species

Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials.

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