Predisposing factors in central retinal vein occlusion (CRVO) have included various systemic disorders and glaucoma. Recent reports have suggested a possible relation between specific anatomic configurations of the optic nerve head and the development of anterior ischemic optic neuropathy. The authors analyzed several optic disc parameters in 57 ocular normotensive patients with unilateral CRVO and in 27 control subjects. There was no significant difference in the horizontal disc diameter and cup-to-disc ratio between eyes with unilateral CRVO, fellow eyes with CRVO, and control eyes. The current data suggest that there is no relation between optic disc size and CRVO.