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      Autophagy Is an Essential Component of Drosophila Immunity against Vesicular Stomatitis Virus

      , , , ,
      Immunity
      Elsevier BV

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          Abstract

          Intrinsic innate immune mechanisms are the first line of defense against pathogens and exist to control infection autonomously in infected cells. Here, we showed that autophagy, an intrinsic mechanism that can degrade cytoplasmic components, played a direct antiviral role against the mammalian viral pathogen vesicular stomatitis virus (VSV) in the model organism Drosophila. We found that the surface glycoprotein, VSV-G, was likely the pathogen-associated molecular pattern (PAMP) that initiated this cell-autonomous response. Once activated, autophagy decreased viral replication, and repression of autophagy led to increased viral replication and pathogenesis in cells and animals. Lastly, we showed that the antiviral response was controlled by the phosphatidylinositol 3-kinase (PI3K)-Akt-signaling pathway, which normally regulates autophagy in response to nutrient availability. Altogether, these data uncover an intrinsic antiviral program that links viral recognition to the evolutionarily conserved nutrient-signaling and autophagy pathways.

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          Author and article information

          Journal
          Immunity
          Immunity
          Elsevier BV
          10747613
          April 2009
          April 2009
          : 30
          : 4
          : 588-598
          Article
          10.1016/j.immuni.2009.02.009
          2754303
          19362021
          781bb87d-14fa-4dd1-8add-b45a73662597
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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