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      Non-coding RNAs in vascular disease – from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

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          Abstract

          <p id="d6536165e221">Non-coding RNAs are increasingly recognized not only as regulators of various biological functions but also as targets for a new generation of RNA therapeutics and biomarkers. We hereby review recent insights relating to non-coding RNAs including microRNAs (e.g. miR-126, miR-146a), long non-coding RNAs (e.g. MIR503HG, GATA6-AS, SMILR), and circular RNAs (e.g. cZNF292) and their role in vascular diseases. This includes identification and therapeutic use of hypoxia-regulated non-coding RNAs and endogenous non-coding RNAs that regulate intrinsic smooth muscle cell signalling, age-related non-coding RNAs, and non-coding RNAs involved in the regulation of mitochondrial biology and metabolic control. Finally, we discuss non-coding RNA species with biomarker potential. </p><p id="d6536165e223">This article is part of the Mini Review Series from the Varenna 2017 meeting of the Working Group of Myocardial Function of the European Society of Cardiology. </p>

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          Author and article information

          Journal
          Cardiovascular Research
          Oxford University Press (OUP)
          0008-6363
          1755-3245
          August 01 2018
          August 01 2018
          May 23 2018
          August 01 2018
          August 01 2018
          May 23 2018
          : 114
          : 10
          : 1281-1286
          Affiliations
          [1 ]Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany
          [2 ]Centre for Cardiovascular Sciences, Queen’s Medical Research Institute, Edinburgh, UK
          [3 ]Institute for Cardiovascular Regeneration, Goethe University, Frankfurt am Main, Germany
          [4 ]Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
          [5 ]Netherlands Heart Institute, Utrecht, The Netherlands
          [6 ]Department of Cardiovascular Sciences, Leuven University, Leuven, Belgium
          [7 ]King's British Heart Foundation Centre, King's College London, London, UK
          [8 ]National Heart and Lung Institute, Imperial College London, London, UK
          [9 ]Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany
          Article
          10.1093/cvr/cvy121
          6054241
          29800267
          782a6c16-3aae-4e7d-ac3f-cc118bd55ed4
          © 2018

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