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      Urinary Tract Infection and Lysozymuria in Uremia

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          Abstract

          Levels of urine and serum lysozyme are elevated in patients whose C<sub>Cr</sub> is below 30 ml/min. In nine patients undergoing maintenance hemodialysis the mean urine and serum lysozyme concentrations were 29.6 and 21.9 µg/ml, respectively, and remained constant with dialysis. In five patients on peritoneal dialysis the mean predialysis urine and serum lysozyme concentrations were 14.9 and 18.5 µg/ml, respectively. An average 17% fall of serum lysozyme concentration was observed post peritoneal dialysis – consistent with protein loss across the peritoneal membrane. Lysozyme in the presence of urine was shown to inhibit bacterial growth of P. mirabilis, E. coli and Pseudomonas sp. Lysozymuria in conjunction with other elements of urine may account for the only moderately increased prevalence of bacteriuria (10<sup>5</sup> col/ml) observed in nondialyzed azotemic patients (22%) and uremic patients supported by hemodialysis (24%).

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1973
          1973
          27 November 2008
          : 10
          : 6
          : 337-346
          Affiliations
          Department of Medicine, Downstate Medical Center, Brooklyn, N. Y.
          Article
          180206 Nephron 1973;10:337–346
          10.1159/000180206
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

          Bacterial inhibition, Lysozymuria, Uremia, Bacteriuria

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