Blog
About

7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Identification of deubiquitinating enzymes involved in methylmercury toxicity in Saccharomyces cerevisiae.

      The Journal of toxicological sciences

      Drug Resistance, Fungal, Endopeptidases, physiology, Methylmercury Compounds, toxicity, Saccharomyces cerevisiae, drug effects, enzymology, Saccharomyces cerevisiae Proteins, Ubiquitination

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Deubiquitinating enzymes that influence the methylmercury susceptibility of yeast cells were investigated. Deficiency of Ubp2, Ubp4, Ubp 6, or Ubp14 conferred methylmercury resistance on cells, while deficiency of Ubp7, Ubp13, or Ubp15 conferred high methylmercury susceptibility. Of these enzymes, deficiency of Ubp4 and Ubp6 was associated with particularly high methylmercury resistance. Yeast cells treated with a proteasome inhibitor showed methylmercury resistance due to Ubp4 deficiency, but not due to Ubp6 deficiency. Thus, the enhanced methylmercury toxicity associated with Ubp6 expression requires proteasomal activity, suggesting that Ubp4 and Ubp6 contribute to enhanced methylmercury toxicity through different mechanisms.

          Related collections

          Author and article information

          Journal
          23208446

          Comments

          Comment on this article