Resolving postoperative neuroinflammation and cognitive decline.

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Abstract

Cognitive decline accompanies acute illness and surgery, especially in the elderly. Surgery engages the innate immune system that launches a systemic inflammatory response that, if unchecked, can cause multiple organ dysfunction. We sought to understand the mechanisms whereby the brain is targeted by the inflammatory response and how this can be resolved.

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Journal

Journal ID (iso-abbrev): Ann Neurol

Title: Annals of neurology

Publisher: Wiley

ISSN (Electronic): 1531-8249

ISSN (Print): 0364-5134

Publication date (Electronic): Dec 2011

Volume: 70

Issue: 6

Affiliations

[1 ] Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143-0648.

[2 ] Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden.

[3 ] Gladstone Institute of Neurological Disease, University of California, San Francisco, CA, USA.

[4 ] Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London W6 8LH, United Kingdom.

[5 ] Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA, USA.

[6 ] Department of Neurology, University of California, San Francisco, CA, USA.

Article

Mid ID: NIHMS334942

DOI: 10.1002/ana.22664

PMC ID: 4556354

PubMed ID: 22190370

SO-VID: 787e3eb3-ebe1-43fd-92f2-b77efd3a18f7

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