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      Resolving postoperative neuroinflammation and cognitive decline.

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          Abstract

          Cognitive decline accompanies acute illness and surgery, especially in the elderly. Surgery engages the innate immune system that launches a systemic inflammatory response that, if unchecked, can cause multiple organ dysfunction. We sought to understand the mechanisms whereby the brain is targeted by the inflammatory response and how this can be resolved.

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          Author and article information

          Journal
          Ann Neurol
          Annals of neurology
          Wiley
          1531-8249
          0364-5134
          Dec 2011
          : 70
          : 6
          Affiliations
          [1 ] Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143-0648.
          [2 ] Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden.
          [3 ] Gladstone Institute of Neurological Disease, University of California, San Francisco, CA, USA.
          [4 ] Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London W6 8LH, United Kingdom.
          [5 ] Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA, USA.
          [6 ] Department of Neurology, University of California, San Francisco, CA, USA.
          Article
          NIHMS334942
          10.1002/ana.22664
          4556354
          22190370
          787e3eb3-ebe1-43fd-92f2-b77efd3a18f7
          Copyright © 2011 American Neurological Association.
          History

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