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      Ebola and Cholera

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          Abstract

          Dear Sir: The description of the clinical course of Ebola virus disease (EVD) provided by Igonoh1 is consistent with mounting evidence indicating that a significant proportion of Ebola mortality is attributable to diarrheal dehydration with severe electrolyte losses.2–6 It is likely that EVD mortality could be reduced below reported levels if therapy could be streamlined as it has been for treatment of cholera. Reports of severe hyponatremia and hypokalemia in EVD suggest that stool sodium and potassium losses may exceed those in the current World Health Organization (WHO) low-sodium oral rehydration solution (ORS). Analysis of EVD stool electrolyte content would help define optimal ORS salt formulations for EVD, but unfortunately have not been reported. Such data are needed to identify the optimal standard ORS composition for EVD treatment.

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          Most cited references 5

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          Ebola virus disease in West Africa--clinical manifestations and management.

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            Clinical care of two patients with Ebola virus disease in the United States.

            West Africa is currently experiencing the largest outbreak of Ebola virus disease (EVD) in history. Two patients with EVD were transferred from Liberia to our hospital in the United States for ongoing care. Malaria had also been diagnosed in one patient, who was treated for it early in the course of EVD. The two patients had substantial intravascular volume depletion and marked electrolyte abnormalities. We undertook aggressive supportive measures of hydration (typically, 3 to 5 liters of intravenous fluids per day early in the course of care) and electrolyte correction. As the patients' condition improved clinically, there was a concomitant decline in the amount of virus detected in plasma.
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              Doing today's work superbly well--treating Ebola with current tools.

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                Author and article information

                Contributors
                Journal
                Am J Trop Med Hyg
                Am. J. Trop. Med. Hyg
                tpmd
                The American Journal of Tropical Medicine and Hygiene
                The American Society of Tropical Medicine and Hygiene
                0002-9637
                1476-1645
                06 May 2015
                06 May 2015
                : 92
                : 5
                : 1081
                Affiliations
                President, Brighton Foundation US. West Chester, PA. E-mail: davidnalin@ 123456aol.com
                Freelance Researcher UK, London, United Kingdom. E-mail: bertzpoet@ 123456yahoo.com
                Article
                10.4269/ajtmh.15-0169
                4426290
                25948558
                ©The American Society of Tropical Medicine and Hygiene

                This is an Open Access article distributed under the terms of the American Society of Tropical Medicine and Hygiene's Re-use License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Categories
                Letters to the Editor

                Infectious disease & Microbiology

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