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      Evaluation of degranulation and cytokine production in natural killer cells from spondyloarthritis patients at single-cell level.

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          Abstract

          A pathogenetic role of natural killer (NK) cells has been hypothesized in spondyloarthritides (SpA), but still conflicting data exist. Aim of this study was to investigate, in a cohort of SpA patients, the peripheral blood NK cell number, the cytokine production (IFNγ and TNFα), and the cytotoxic activity on target cell stimulation. Moreover, we aimed to evaluate the expression of KIR3DL1, an inhibitory receptor binding HLA class I alleles, including HLA-B27 strongly associated with SpA, between different NK cell subsets.

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          Author and article information

          Journal
          Cytometry B Clin Cytom
          Cytometry. Part B, Clinical cytometry
          Wiley
          1552-4957
          1552-4949
          Jan 2011
          : 80
          : 1
          Affiliations
          [1 ] Dipartimento di Clinica e Terapia Medica, Reumatologia, Sapienza Universita' di Roma, Italy. rossanascrivo@hotmail.com
          Article
          10.1002/cyto.b.20549
          20687202
          7883d436-5cae-43da-b07e-576f6a057377
          History

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