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      Myofibroblast – like cells and liver fibrogenesis: Emerging concepts in a rapidly moving scenario

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      Molecular Aspects of Medicine

      Elsevier BV

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          Abstract

          Fibrotic progression of chronic liver diseases of different aetiology to the common advanced-stage of cirrhosis can be envisaged as a dynamic and highly integrated cellular response to chronic liver injury. Liver fibrosis is accompanied by perpetuation of liver injury, chronic hepatitis and persisting activation of tissue repair mechanisms, leading eventually to excess deposition of ECM components. Liver fibrogenesis (i.e., the process) is sustained by populations of highly proliferative, pro-fibrogenic and contractile MFs that, according to current literature, originate by a process of activation involving perisinusoidal HSC, portal fibroblasts and even bone marrow-derived MSC. In this short review emerging concepts in hepatic fibrogenesis and related molecular mechanisms, as provided by recent experimental and clinical studies, are presented.

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          Author and article information

          Journal
          Molecular Aspects of Medicine
          Molecular Aspects of Medicine
          Elsevier BV
          00982997
          February 2008
          February 2008
          : 29
          : 1-2
          : 58-66
          Article
          10.1016/j.mam.2007.09.002
          18022682
          © 2008

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