The Hemolytic-Uremic Syndrome

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Abstract

The clinical and pathological characteristics of the acute stage of the HUS are described on the basis of 678 patients and the study of 52 autopsies and 3 kidney biopsies. The laboratory and pathological studies point to DIC as a basic pathogenic mechanism, probably related to a viral infection. The recent mortality rate has been 6.25% due to the exacting dialysis treatment employed. Heparin was ineffective in the 26 patients in which it was used. 124 patients have a follow-up of more than 5 years and up to 13 years. 60 patients are completely recovered, while 64 have persistent signs of renal disease. Nine other children died in uremia 1–12 years after onset. The pathological findings are discussed on the basis of 6 autopsies and 24 biopsies in 27 patients. This stage of the HUS appears as an important and new aspect of pediatric nephrology.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISBN: 978-3-8055-2578-7

ISBN: 978-3-318-02105-9

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1973

Publication date (Print): 1973

Publication date (Electronic): 28 November 2008

Volume: 11

Issue: 2-4

Pages: 174-192

Affiliations

Hospital de Niños, Buenos Aires

Article

Publisher ID: 180229 Other ID: Nephron 1973;11:174–192

DOI: 10.1159/000180229

PubMed ID: 4542964

SO-VID: 78aaaa7d-5da9-4ae9-b94c-5fa3fb5c20d8

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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Pages: 19

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