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      The Hemolytic-Uremic Syndrome

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      Nephron

      S. Karger AG

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          Abstract

          The clinical and pathological characteristics of the acute stage of the HUS are described on the basis of 678 patients and the study of 52 autopsies and 3 kidney biopsies. The laboratory and pathological studies point to DIC as a basic pathogenic mechanism, probably related to a viral infection. The recent mortality rate has been 6.25% due to the exacting dialysis treatment employed. Heparin was ineffective in the 26 patients in which it was used. 124 patients have a follow-up of more than 5 years and up to 13 years. 60 patients are completely recovered, while 64 have persistent signs of renal disease. Nine other children died in uremia 1–12 years after onset. The pathological findings are discussed on the basis of 6 autopsies and 24 biopsies in 27 patients. This stage of the HUS appears as an important and new aspect of pediatric nephrology.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-2578-7
          978-3-318-02105-9
          1660-8151
          2235-3186
          1973
          1973
          28 November 2008
          : 11
          : 2-4
          : 174-192
          Affiliations
          Hospital de Niños, Buenos Aires
          Article
          180229 Nephron 1973;11:174–192
          10.1159/000180229
          4542964
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 19
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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