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      Jatrogricaine A: a new diterpenoid with a 5/6/6/4 carbon ring system from the stems of Jatropha podagrica

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          Abstract

          Jatrogricaine A ( 1), a new diterpenoid possessing a 5/6/6/4 carbon ring system, together with eight known diterpenoids ( 29) were isolated from the stems of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods and the absolute configuration of 1 was determined by single crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory activities in vitro, and compound 3 showed significant inhibitory effects against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells with an IC 50 of 13.44 + 0.28 μmol-L -1, being comparable to the positive control, quercetin (IC50 17.00 + 2.10 μmol-L -1).

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 April 2019
          : 17
          : 4
          : 298-302
          Affiliations
          1 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
          2 Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China
          Author notes
          *Corresponding author: YIN Sheng, E-mail: yinsh2@ 123456mail.sysu.edu.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30033-0
          10.1016/S1875-5364(19)30033-0
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81573302
          Award ID: 81722042
          Funded by: cience and Technology Planning Project of Guangdong Province
          Award ID: 2015A020211007
          Funded by: Guangdong Natural Science Funds for Distinguished Young Scholar
          Award ID: 2014A030306047
          This work was supported by the National Natural Science Foundation of China (Nos. 81573302 and 81722042), the Science and Technology Planning Project of Guangdong Province (No. 2015A020211007), and the Guangdong Natural Science Funds for Distinguished Young Scholar (No. 2014A030306047).

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