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      Gut–organ axis: a microbial outreach and networking

      1 , 1 , 1
      Letters in Applied Microbiology
      Wiley

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          Abstract

          <p class="first" id="d2474075e66">Human gut microbiota (GM) includes a complex and dynamic population of microorganisms that are crucial for well-being and survival of the organism. It has been reported as diverse and relatively stable with shared core microbiota, including Bacteroidetes and Firmicutes as the major dominants. They are the key regulators of body homeostasis, involving both intestinal and extra-intestinal effects by influencing many physiological functions such as metabolism, maintenance of barrier homeostasis, inflammation and hematopoiesis. Any alteration in GM community structures not only trigger gut disorders but also influence other organs and cause associated diseases. In recent past, the GM has been defined as a 'vital organ' with its involvement with other organs; thus, establishing a link or a bi- or multidirectional communication axis between the organs via neural, endocrine, immune, humoral and metabolic pathways. Alterations in GM have been linked to several diseases known to humans; although the exact interaction mechanism between the gut and the organs is yet to be defined. In this review, the bidirectional relationship between the gut and the vital human organs was envisaged and discussed under several headings. Furthermore, several disease symptoms were also revisited to redefine the communication network between the gut microbes and the associated organs. </p>

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          Author and article information

          Journal
          Letters in Applied Microbiology
          Lett Appl Microbiol
          Wiley
          0266-8254
          1472-765X
          July 16 2020
          Affiliations
          [1 ]Laboratory of Enzymology and Recombinant DNA Technology Department of Microbiology Maharshi Dayanand University Rohtak Haryana India
          Article
          10.1111/lam.13333
          32472555
          78c4fc92-5809-4767-b22f-ef2a58c03ffa
          © 2020

          http://onlinelibrary.wiley.com/termsAndConditions#vor

          http://doi.wiley.com/10.1002/tdm_license_1.1

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