Two New Withanolide Lactones from Flos Daturae

Abstract

Chemical investigation of the 50% ethanol eluate fraction from a macroporous resin of flowers of Datura metel L. collected in the Jiangsu Province of China resulted in the isolation of two new withanolides, baimantuoluoline G ( 1) and baimantuoluoside H ( 2). Their structures were elucidated as (12 β,6 β,22 R)-1,10-seco-6,12,27-trihydroxy-26-oxo-witha-3,5,24-trienolide-1-oic acid- ε-lactone ( 1) and (5 β,6 α,12 β,22 R)-5,6,12,27-tetra-hydroxy-1,26-dioxo-witha-2,24-dienolide-27-O- β-glucopyranoside ( 2) on the basis of extensive spectroscopic analysis (1D, 2D-NMR and HRESIMS) and chemical studies.