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      Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis.

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          Abstract

          Cystathionine γ-lyase (CSE) produces hydrogen sulfide (H2S) in the cardiovascular system. The deficiency of CSE in mice leads to a decreased endogenous H2S level, an age-dependent increase in blood pressure, and impaired endothelium-dependent vasorelaxation. To date, there is no direct evidence for a causative role of altered metabolism of endogenous H2S in atherosclerosis development.

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          Author and article information

          Journal
          Circulation
          Circulation
          Ovid Technologies (Wolters Kluwer Health)
          1524-4539
          0009-7322
          Jun 25 2013
          : 127
          : 25
          Affiliations
          [1 ] Department of Biology, Lakehead University, Thunder Bay, ON, Canada.
          Article
          CIRCULATIONAHA.113.002208
          10.1161/CIRCULATIONAHA.113.002208
          23704252
          78ccad98-f556-46ad-8d36-ee64ef34e8d9
          History

          apolipoprotein E,atherosclerosis,cystathionine γ-lyase,hydrogen sulfide,oxidative stress

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