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      Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects.

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          Abstract

          Sputum eosinophil percentages are a strong predictor of airway inflammation and exacerbations and aid asthma management, whereas sputum neutrophil percentages indicate a different severe asthma phenotype that is potentially less responsive to TH2-targeted therapy. Variables, such as blood eosinophil counts, total IgE levels, fraction of exhaled nitric oxide (Feno) levels, or FEV1 percent predicted, might predict airway eosinophil percentages, whereas age, FEV1 percent predicted, or blood neutrophil counts might predict sputum neutrophil percentages. Availability and ease of measurement are useful characteristics, but accuracy in predicting airway eosinophil and neutrophil percentages either individually or combined is not established.

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          Author and article information

          Journal
          J. Allergy Clin. Immunol.
          The Journal of allergy and clinical immunology
          1097-6825
          0091-6749
          Jul 2013
          : 132
          : 1
          Affiliations
          [1 ] Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. ahastie@wakehealth.edu
          Article
          S0091-6749(13)00583-6 NIHMS483672
          10.1016/j.jaci.2013.03.044
          23706399
          78cd928c-8da5-4206-bfa8-d73825ec54ed
          Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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