For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
24
views
58
references
 Top references
cited by
22
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      65
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Microbiota and Human Reproduction: The Case of Male Infertility

      review-article

      Read this article at

      ScienceOpenPublisherPMC
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The increasing interest in metagenomics is enhancing our knowledge regarding the composition and role of the microbiota in human physiology and pathology. Indeed, microbes have been reported to play a role in several diseases, including infertility. In particular, the male seminal microbiota has been suggested as an important factor able to influence couple’s health and pregnancy outcomes, as well as offspring health. Nevertheless, few studies have been carried out to date to deeper investigate semen microbiome origins and functions, and its correlations with the partner’s reproductive tract microbiome. Here, we report the state of the art regarding the male reproductive system microbiome and its alterations in infertility.

          Related collections

          Most cited references58

          • Record: found
          • Abstract: found
          • Article: not found

          Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection.

          Harold C. Wiesenfeld, Sharon L Hillier, Marijane Krohn … (2003)
          To evaluate whether bacterial vaginosis predicts the acquisition of sexually transmitted diseases (STDs), we studied 255 nonpregnant female subjects aged 15-30 who reported recent sexual contact with a male partner in whom either gonococcal or chlamydial urethritis or nongonococcal urethritis was diagnosed. Compared to subjects with normal vaginal flora, subjects with bacterial vaginosis were more likely to test positive for Neisseria gonorrhoeae (odds ratio [OR], 4.1; 95% confidence interval [CI], 1.7-9.7) and Chlamydia trachomatis (OR, 3.4; 95% CI, 1.5-7.8). Subjects colonized vaginally by hydrogen peroxide-producing lactobacilli were less likely to receive a diagnosis of chlamydial infection or gonorrhea than subjects without such lactobacilli. Bacterial vaginosis was a strong predictor of gonorrhea and chlamydial infection among subjects who reported recent exposure to a male partner with urethritis. These data support the importance of vaginal flora in the defense against STD acquisition.
          Article 0 comments Cited 179 times – based on 0 reviews     Review now
            • Record: found
            • Abstract: found
            • Article: not found
            Is Open Access

            The role of the gut microbiome in the healthy adult status.

            Valeria D’Argenio, Francesco Salvatore (2015)
            The gut microbiome, which hosts up to 1000 bacterial species that encode about 5 million genes, perform many of the functions required for host physiology and survival. Consequently, it is also known as "our forgotten organ". The recent development of next-generation sequencing technologies has greatly improved metagenomic research. In particular, it has increased our knowledge about the microbiome and its mutually beneficial relationships with the human host. Microbial colonization begins immediately at birth. Although influenced by a variety of stimuli, namely, diet, physical activity, travel, illness, hormonal cycles and therapies, the microbiome is practically stable in healthy adults. This suggests that the microbiome plays a role in the maintenance of a healthy state in adulthood. Quantitative and qualitative alterations in the composition of the gut microbiome could lead to pathological dysbiosis, and have been related to an increasing number of intestinal and extra-intestinal diseases. With the increase in knowledge about gut microbiome functions, it is becoming increasingly more possible to develop novel diagnostic, prognostic and, most important, therapeutic strategies based on microbiome manipulation.
            Article 0 comments Cited 166 times – based on 0 reviews     Review now
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Role of Oxidative Stress in Male Infertility: An Updated Review

              Ahmed Alahmar (2019)
              Current evidence links oxidative stress (OS) to male infertility, reduced sperm motility, sperm DNA damage and increased risk of recurrent abortions and genetic diseases. A review of PubMed, Medline, Google Scholar, and Cochrane review databases of published articles from years 2000–2018 was performed focusing on physiological and pathological consequences of reactive oxygen species (ROS), sperm DNA damage, OS tests, and the association between OS and male infertility, pregnancy and assisted reproductive techniques outcomes. Generation of ROS is essential for reproductive function, but OS is detrimental to fertility, pregnancy, and genetic status of the newborns. Further, there is a lack of consensus on selecting OS test, type, and duration of antioxidants treatment as well as on the target patients group. Developing advanced diagnostic and therapeutic options for OS is essential to improve fertility potential and limit genetic diseases transmitted to offspring.
              Article 0 comments Cited 131 times – based on 0 reviews     Review now
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): High Throughput
                Journal ID (iso-abbrev): High Throughput
                Journal ID (publisher-id): high-throughput
                Title: High-Throughput
                Publisher: MDPI
                ISSN (Electronic): 2571-5135
                Publication date (Electronic): 13 April 2020
                Publication date Collection: June 2020
                Volume: 9
                Issue: 2
                Electronic Location Identifier: 10
                Affiliations
                [1 ]KronosDNA srl, spinoff of Università Federico II, 80133 Napoli, Italy; rossella.tomaiuolo@ 123456unina.it (R.T.); cariati@ 123456ceinge.unina.it (F.C.)
                [2 ]Department of Molecular Medicine and Medical Biotechnologies, Federico II University, Via Sergio Pansini 5, 80131 Napoli, Italy; io.veneruso@ 123456studenti.unina.it
                [3 ]CEINGE-Biotecnologie Avanzate scarl, Via Gaetano Salvatore 486, 80145 Napoli, Italy
                [4 ]Department of Human Sciences and Quality of Life Promotion, San Raffaele Open University, 00166 Roma, Italy
                Author notes
                [* ]Correspondence: dargenio@ 123456ceinge.unina.it ; Tel.: +39-081-3737909
                Author information
                https://orcid.org/0000-0001-9273-3698
                Article
                Publisher ID: high-throughput-09-00010
                DOI: 10.3390/ht9020010
                PMC ID: 7349524
                PubMed ID: 32294988
                SO-VID: 78d1ec64-caf1-49d2-a024-9d2b0a497d15
                Copyright © © 2020 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 13 March 2020
                Date accepted : 09 April 2020
                Categories
                Subject: Review

                Keywords: microbiota,human microbiome,human reproduction,male infertility,semen microbiome
                Data availability:
                Keywords: microbiota, human microbiome, human reproduction, male infertility, semen microbiome

                Comments

                Comment on this article

                Related Documents Log
                scite_

                Similar content65

                See all similar

                Cited by22

                See all cited by

                Most referenced authors659

                See all reference authors