Genome Sequence of Roseovarius mucosus Strain SMR3, Isolated from a Culture of the Diatom Skeletonema marinoi

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ABSTRACT

We present the genome of Roseovarius mucosus strain SMR3, a marine bacterium isolated from the diatom Skeletonema marinoi strain RO5AC sampled from top layer sediments at 14 m depth. Its 4,381,426 bp genome consists of a circular chromosome and two circular plasmids and contains 4,178 coding sequences (CDSs).

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Biosynthesis of phosphatidylcholine in bacteria.

Christian Sohlenkamp, Isabel López-Lara, Otto Geiger (2003)

Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes and can be synthesized by either of two pathways, the methylation pathway or the CDP-choline pathway. Many prokaryotes lack PC, but it can be found in significant amounts in membranes of rather diverse bacteria and based on genomic data, we estimate that more than 10% of all bacteria possess PC. Enzymatic methylation of phosphatidylethanolamine via the methylation pathway was thought to be the only biosynthetic pathway to yield PC in bacteria. However, a choline-dependent pathway for PC biosynthesis has been discovered in Sinorhizobium meliloti. In this pathway, PC synthase, condenses choline directly with CDP-diacylglyceride to form PC in one step. A number of symbiotic (Rhizobium leguminosarum, Mesorhizobium loti) and pathogenic (Agrobacterium tumefaciens, Brucella melitensis, Pseudomonas aeruginosa, Borrelia burgdorferi and Legionella pneumophila) bacteria seem to possess the PC synthase pathway and we suggest that the respective eukaryotic host functions as the provider of choline for this pathway. Pathogens entering their hosts through epithelia (Streptococcus pneumoniae, Haemophilus influenzae) require phosphocholine substitutions on their cell surface components that are biosynthetically also derived from choline supplied by the host. However, the incorporation of choline in these latter cases proceeds via choline phosphate and CDP-choline as intermediates. The occurrence of two intermediates in prokaryotes usually found as intermediates in the eukaryotic CDP-choline pathway for PC biosynthesis raises the question whether some bacteria might form PC via a CDP-choline pathway.

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Author and article information

Journal

Journal ID (nlm-ta): Genome Announc

Journal ID (iso-abbrev): Genome Announc

Journal ID (hwp): ga

Journal ID (pmc): ga

Journal ID (publisher-id): GA

Title: Genome Announcements

Publisher: American Society for Microbiology (1752 N St., N.W., Washington, DC )

ISSN (Electronic): 2169-8287

Publication date (Electronic): 1 June 2017

Publication date Collection: June 2017

Volume: 5

Issue: 22

Electronic Location Identifier: e00394-17

Affiliations

[a ]Department of Marine Sciences, University of Gothenburg, Göteborg, Sweden

[b ]Gothenburg Global Biodiversity Centre, Göteborg, Sweden

[c ]Department of Biological and Environmental Sciences, University of Gothenburg, Göteborg, Sweden

Author notes

Address correspondence to Mats Töpel, mats.topel@ 123456marine.gu.se .

M.T. and M.I.M.P. contributed equally to this work.

Author information

Mats Töpel http://orcid.org/0000-0001-7989-696X

Article

Publisher ID: genomeA00394-17

DOI: 10.1128/genomeA.00394-17

PMC ID: 5454192

PubMed ID: 28572309

SO-VID: 79079534-5a07-408b-a5c9-62c8faae37ba

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

History

Date received : 30 March 2017

Date accepted : 11 April 2017

Page count

Figures: 0, Tables: 0, Equations: 0, References: 6, Pages: 2, Words: 970

Funding

Funded by: Swedish Research Council VR

Award ID: 2015-04286

Award Recipient : Adrian K. Clarke

Funded by: Svenska Forskningsrådet Formas (Swedish Research Council Formas) https://doi.org/10.13039/501100001862

Award ID: 219-2012-2070

Award Recipient : Anna Godhe

Funded by: Gordon and Betty Moore Foundation (Gordon E. and Betty I. Moore Foundation) https://doi.org/10.13039/100000936

Award ID: 4967

Award Recipient : Mats Töpel Award Recipient : Anna Godhe Award Recipient : Adrian K. Clarke

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cover-date June 2017

ScienceOpen disciplines: Genetics

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ScienceOpen disciplines: Genetics

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