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      Smooth Muscle Cells in the Development of Plasmatic Arterionecrosis, Arteriosclerosis, and Arterial Contraction


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          Plasmatic arterionecrosis, the causative lesion of hypertensive cerebral hemorrhage, follows upon medial muscle cell necrosis. The development of medial muscle cell necrosis, the earliest cerebral arterial change seen in hypertensive rats, was inhibited when these animals were fed a cholesterol and lard-supplemented diet. Insudation of fibrin was noted in the arterial intima of hypertensive rats with bilaterally constricted renal arteries. Removal of the constriction induced a fall in the elevated blood pressure and an increase of intimal muscle cells. These were responsible for the dissolution of the deposited fibrin, leading to arteriosclerosis. These myointimal cells may originate from the endothelium. Arterial contraction caused by methoxamine hydrochloride often induced the intrusion of one medial muscle cell into another and increased endothelial permeability. 12–24 h after contraction, the arterial segments showed medial muscle cell necrosis, endothelial desquamation with platelet adhesion, and blood plasma infiltration.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 15
          : 1-3
          : 148-156
          Department of Pathology, School of Medicine, Gunma University, Maebashi
          158160 Blood Vessels 1978;15:148–156
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 9
          Molecular and Cellular Aspects of Vascular Smooth Muscle in Health and Disease

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Methoxamine hydrochloride,Intrusion of smooth muscle cell,Myointimal cell,Arterial contraction,Arterionecrosis,Arteriosclerosis


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