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      What Happened to Intravenous Atenolol in Acute Myocardial Infarction?

      Cardiology

      S. Karger AG

      Acute myocardial infarction, Atenolol, Beta blockers, GISSI, ISIS

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          Abstract

          Randomized clinical trials are essential in objectively assessing treatment options. However, badly designed trials can generate impressive results, and good trial data may be interpreted differently by practicing clinicians. One example of the latter is the use of intravenous atenolol in acute myocardial infarction where, despite a large trial clearly demonstrating that immediate therapy is relatively safe in patients with acute myocardial infarction and reduces in-hospital mortality, its routine use remains extremely variable. The reasons for the poor uptake of atenolol in acute myocardial infarction, including anticipated clinical drawbacks, the way the trial data were published, and the marketing of beta blockers, are discussed in this paper.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-6144-0
          978-3-318-01954-4
          0008-6312
          1421-9751
          1994
          1994
          18 November 2008
          : 85
          : Suppl 1
          : 13-17
          Affiliations
          John Radcliffe Hospital, Oxford, UK
          Article
          176752 Cardiology 1994;85:13–17
          10.1159/000176752
          7743529
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Session I: Use and Abuse of Clinical Trials

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