Xueying Tian 1 , Tianyuan Hu 1 , Hui Zhang 1 , Lingjuan He 1 , Xiuzhen Huang 1 , Qiaozhen Liu 1 , Wei Yu 1 , Liang He 1 , Zhen Yang 2 , Yan Yan 2 , Xiao Yang 3 , Tao P Zhong 4 , William T Pu 5 , Bin Zhou 6
Jul 04 2014
The postnatal coronary vessels have been viewed as developing through expansion of vessels formed during the fetal period. Using genetic lineage tracing, we found that a substantial portion of postnatal coronary vessels arise de novo in the neonatal mouse heart, rather than expanding from preexisting embryonic vasculature. Our data show that lineage conversion of neonatal endocardial cells during trabecular compaction generates a distinct compartment of the coronary circulation located within the inner half of the ventricular wall. This lineage conversion occurs within a brief period after birth and provides an efficient means of rapidly augmenting the coronary vasculature. This mechanism of postnatal coronary vascular growth provides avenues for understanding and stimulating cardiovascular regeneration following injury and disease.