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      Correction: Sarcopenia and sarcopenic obesity are independent adverse prognostic factors in resectable pancreatic ductal adenocarcinoma

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          Abstract

          There are errors in the author affiliations. The correct affiliations are as follows: Elisabeth S. Gruber1.3, Gerd Jomrich1,3, Dietmar Tamandl2, Michael Gnant3, Martin Schindl1,3, Klaus Sahora1,3 1 Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria, 2 Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3 Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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          Sarcopenia and sarcopenic obesity are independent adverse prognostic factors in resectable pancreatic ductal adenocarcinoma

          Elisabeth Gruber, Gerd Jomrich, Dietmar Tamandl … (2019)
          Background Incidence and mortality of pancreatic ductal adenocarcinoma (PDAC) are on the rise. Sarcopenia and sarcopenic obesity have proven to be prognostic factors in different types of cancers. In the context of previous findings, we evaluated the impact of body composition in patients undergoing surgery in a national pancreatic center. Methods Patient’s body composition (n = 133) was analyzed on diagnostic CT scans and defined as follows: Skeletal muscle index ≤38.5 cm2/m2 (women), ≤52.4 cm2/m2 (men); obesity was classified as BMI ≥25kg/m2. Results Sarcopenia showed a negative impact on overall survival (OS; 14 vs. 20 months, p = 0.016). Sarcopenic patients suffering from obesity showed poorer OS compared to non-sarcopenic obese patients (14 vs. 23 months, p = 0.007). Both sarcopenia and sarcopenic obesity were associated with sex (p<0.001 and p = 0.006; males vs. females 20% vs. 38% and 12% vs. 38%, respectively); sarcopenia was further associated with neoadjuvant treatment (p = 0.025), tumor grade (p = 0.023), weight loss (p = 0.02) and nutritional depletion (albumin, p = 0.011) as well as low BMI (<25 kg/m2, p = 0.038). Sarcopenic obese patients showed higher incidence of major postoperative complications (p<0.001). In addition, sarcopenia proved as an independent prognostic factor for OS (p = 0.031) in the multivariable Cox Regression model. Conclusion Patients with sarcopenia and sarcopenic obesity undergoing resection for PDAC have a significantly shorter overall survival and a higher complication rate. The assessment of body composition in these patients may provide a broader understanding of patients’ individual condition and guide specific supportive strategies in patients at risk.
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            Journal
            Journal ID (nlm-ta): PLoS One
            Journal ID (iso-abbrev): PLoS One
            Journal ID (publisher-id): plos
            Journal ID (pmc): plosone
            Title: PLoS ONE
            Publisher: Public Library of Science (San Francisco, CA USA )
            ISSN (Electronic): 1932-6203
            Publication date (Electronic): 29 December 2020
            Publication date Collection: 2020
            Publication date PMC-release: 29 December 2020
            Volume: 15
            Issue: 12
            Electronic Location Identifier: e0244896
            Article
            Publisher ID: PONE-D-20-39841
            DOI: 10.1371/journal.pone.0244896
            PMC ID: 7771687
            PubMed ID: 33373414
            SO-VID: 792bacc3-a4d2-45ef-b486-5656d379eb82
            Copyright © © 2020 Gruber et al
            License:

            This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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            Sarcopenia and sarcopenic obesity are independent adverse prognostic factors in resectable pancreatic ductal adenocarcinoma
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