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      Structural determination of eleven new preschisanartane-type schinortriterpenoids from two Schisandra species and structural revision of preschisanartanin J using NMR computation method

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          Abstract

          Nineteen preschisanartane-type schinortriterpenoids (SNTs), among which eleven ones were previously undescribed, were isolated from two Schisandra species, S. sphaerandra and S. rubriflora. Their structures were determined using 1D and 2D NMR spectroscopic analyses, NMR data comparison, quantum chemical calculation of NMR parameters, electronic circular dichroism (ECD), X-ray single crystal diffraction, and chemical derivation. Furthermore, structural re-examination of a few previously reported preschisanartane-type SNTs led to the structural revision of preschisanartanin J. Besides, it is suggested that the reported structures of arisanlactone D and schilancidilactone W should be re-checked. Finally, a few isolated SNTs were found to possess neurite outgrowth- promoting activities, and protective activities against neural injuries.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier BV
          1875-5364
          20 December 2019
          : 17
          : 12
          : 970-981
          Affiliations
          1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
          Author notes
          *Corresponding author: PUNO Pema-Tenzin, E-mail: punopematenzin@ 123456mail.kib.ac.cn

          These authors have no conflict of interest to declare.

          Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday

          Article
          S1875-5364(19)30120-7
          10.1016/S1875-5364(19)30120-7
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81903520
          Funded by: Second Tibetan Plateau Scientific Expedition and Research (STEP) program
          Award ID: 2019QZKK0502
          This work was supported by the National Natural Science Foundation of China (No. 81903520) and the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (No. 2019QZKK0502).
          Categories
          Research article

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