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      Motion Parallax Improves Object Recognition in the Presence of Clutter in Simulated Prosthetic Vision

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          Abstract

          Purpose

          Efficacy of current visual prostheses in object recognition is limited. Among various limitations to be addressed, such as low resolution and low dynamic range, here we focus on reducing the impact of background clutter on object recognition. We have proposed the use of motion parallax via head-mounted camera lateral scanning and computationally stabilizing the object of interest (OI) to support neural background decluttering. Simulations in head-mounted displays (HMD), mimicking the proposed effect, were used to test object recognition in normally sighted subjects.

          Methods

          Images (24° field of view) were captured from multiple viewpoints and presented at a low resolution (20 × 20). All viewpoints were centered on the OI. Experimental conditions (2 × 3) included clutter (with or without) × head scanning (single viewpoint, 9 coherent viewpoints corresponding to subjects' head positions, and 9 randomly associated viewpoints). Subjects used lateral head movements to view OIs in the HMD. Each object was displayed only once for each subject.

          Results

          The median recognition rate without clutter was 40% for all head scanning conditions. Performance with synthetic background clutter dropped to 10% in the static condition, but it was improved to 20% with the coherent and random head scanning (corrected P = 0.005 and P = 0.049, respectively).

          Conclusions

          Background decluttering using motion parallax cues but not the coherent multiple views of the OI improved object recognition in low-resolution images. The improvement did not fully eliminate the impact of background.

          Translational Relevance

          Motion parallax is an effective but incomplete decluttering solution for object recognition with visual prostheses.

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          Most cited references40

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          Interim results from the international trial of Second Sight's visual prosthesis.

          This study evaluated the Argus II Retinal Prosthesis System (Second Sight Medical Products, Inc., Sylmar, CA) in blind subjects with severe outer retinal degeneration. Single-arm, prospective, multicenter clinical trial. Thirty subjects were enrolled in the United States and Europe between June 6, 2007, and August 11, 2009. All subjects were followed up for a minimum of 6 months and up to 2.7 years. The electronic stimulator and antenna of the implant were sutured onto the sclera using an encircling silicone band. Next, a pars plana vitrectomy was performed, and the electrode array and cable were introduced into the eye via a pars plana sclerotomy. The microelectrode array then was tacked to the epiretinal surface. The primary safety end points for the trial were the number, severity, and relation of adverse events. Principal performance end points were assessments of visual function as well as performance on orientation and mobility tasks. Subjects performed statistically better with the system on versus off in the following tasks: object localization (96% of subjects), motion discrimination (57%), and discrimination of oriented gratings (23%). The best recorded visual acuity to date is 20/1260. Subjects' mean performance on orientation and mobility tasks was significantly better when the system was on versus off. Seventy percent of the patients did not have any serious adverse events (SAEs). The most common SAE reported was either conjunctival erosion or dehiscence over the extraocular implant and was treated successfully in all subjects except in one, who required explantation of the device without further complications. The long-term safety results of Second Sight's retinal prosthesis system are acceptable, and most subjects with profound visual loss perform better on visual tasks with system than without it. Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
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            Subretinal Visual Implant Alpha IMS--Clinical trial interim report.

            A subretinal visual implant (Alpha IMS, Retina Implant AG, Reutlingen, Germany) was implanted in 29 blind participants with outer retinal degeneration in an international multicenter clinical trial. Primary efficacy endpoints of the study protocol were a significant improvement of activities of daily living and mobility to be assessed by activities of daily living tasks, recognition tasks, mobility, or a combination thereof. Secondary efficacy endpoints were a significant improvement of visual acuity/light perception and/or object recognition (clinicaltrials.gov, NCT01024803). During up to 12 months observation time twenty-one participants (72%) reached the primary endpoints, of which thirteen participants (45%) reported restoration of visual function which they use in daily life. Additionally, detection, localization, and identification of objects were significantly better with the implant power switched on in the first 3 months. Twenty-five participants (86%) reached the secondary endpoints. Measurable grating acuity was up to 3.3 cycles per degree, visual acuities using standardized Landolt C-rings were 20/2000, 20/2000, 20/606 and 20/546. Maximal correct motion perception ranged from 3 to 35 degrees per second. These results show that subretinal implants can restore very-low-vision or low vision in blind (light perception or less) patients with end-stage hereditary retinal degenerations.
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              The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss

              Background Retinal prosthesis systems (RPS) are a novel treatment for profound vision loss in outer retinal dystrophies. Ideal prostheses would offer stable, long-term retinal stimulation and reproducible spatial resolution in a portable form appropriate for daily life. Methods We report a prospective, internally controlled, multicentre trial of the Argus II system. Twenty-eight subjects with light perception vision received a retinal implant. Controlled, closed-group, forced-choice letter identification, and, open-choice two-, three- and four-letter word identification tests were carried out. Results The mean±SD percentage correct letter identification for 21 subjects tested were: letters L, T, E, J, F, H, I, U, 72.3±24.6% system on and 17.7±12.9% system off; letters A, Z, Q, V, N, W, O, C, D, M, 55.0±27.4% system on and 11.8%±10.7% system off, and letters K, R, G, X, B, Y, S, P, 51.7±28.9% system on and 15.3±7.4% system off. (p<0.001 for all groups). A subgroup of six subjects was able to consistently read letters of reduced size, the smallest measuring 0.9 cm (1.7°) at 30 cm, and four subjects correctly identify unrehearsed two-, three- and four-letter words. Average implant duration was 19.9 months. Conclusions Multiple blind subjects fitted with the Argus II system consistently identified letters and words using the device, indicating reproducible spatial resolution. This, in combination with stable, long-term function, represents significant progress in the evolution of artificial sight.
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                Author and article information

                Journal
                Transl Vis Sci Technol
                Transl Vis Sci Technol
                tvst
                Transl Vis Sci Technol
                TVST
                Translational Vision Science & Technology
                The Association for Research in Vision and Ophthalmology
                2164-2591
                September 2018
                29 October 2018
                : 7
                : 5
                : 29
                Affiliations
                [1 ]The Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
                [2 ]Department of Psychology, University of Pennsylvania Philadelphia, PA, USA
                Author notes
                Correspondence: Eli Peli, Schepens Eye Research Institute, 20 Staniford St, Boston, MA 02114, USA. e-mail: eli_peli@ 123456meei.harvard.edu
                [*]

                CQ and KRL contributed equally to this article.

                Article
                tvst-07-05-19 TVST-18-0747
                10.1167/tvst.7.5.29
                6205682
                7948c2f2-3adf-4b90-abd4-f2206fe6040b
                Copyright 2018 The Authors

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 5 February 2018
                : 31 July 2018
                Categories
                Articles

                visual prosthesis,object recognition,motion parallax,sensory substitution device

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