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      Particle radiation therapy using proton and heavier ion beams.

      Journal of clinical oncology : official journal of the American Society of Clinical Oncology

      Brain Neoplasms, radiotherapy, Heavy Ions, therapeutic use, Humans, Lung Neoplasms, Male, Melanoma, Neoplasms, Prostatic Neoplasms, Protons, Radiotherapy Dosage, Skull Base Neoplasms, Uveal Neoplasms

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          Abstract

          Particle beams like protons and heavier ions offer improved dose distributions compared with photon (also called x-ray) beams and thus enable dose escalation within the tumor while sparing normal tissues. Although protons have a biologic effectiveness comparable to photons, ions, because they are heavier than protons, provide a higher biologic effectiveness. Recent technologic developments in the fields of accelerator engineering, treatment planning, beam delivery, and tumor visualization have stimulated the process of transferring particle radiation therapy (RT) from physics laboratories to the clinic. This review describes the physical, biologic, and technologic aspects of particle beam therapy. Clinical trials investigating proton and carbon ion RT will be summarized and discussed in the context of their relevance to recent concepts of treatment with RT.

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          Journal
          17350944
          10.1200/JCO.2006.09.7816

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