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      Relative Bioavailability of Ethinyl Estradiol from Two Different Oral Contraceptive Formulations after Single Oral Administration to 18 Women in an Intraindividual Cross-Over Design

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          Abstract

          Two low-dose oral contraceptives, both containing the same dose of ethinyl estradiol (EE<sub>2</sub>) but different progestins (gestodene and desogestrel, respectively), were compared with respect to the relative bioavailability of EE<sub>2</sub>. After single-dose administration of both formulations to 18 women in an intraindividual cross-over design, there was no difference in the target variables for EE<sub>2</sub> (C<sub>max</sub>, t<sub>max</sub> and AUC). With respect to EE<sub>2</sub>, both formulations were bioequivalent. The observation of others, reporting higher EE<sub>2</sub> levels in the serum of women taking the gestodene-containing formulation as compared to those taking the desogestrel-containing formulation, was not confirmed.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1990
          1990
          02 December 2008
          : 33
          : 1
          : 40-44
          Affiliations
          Schering AG Research Laboratories, Berlin/Bergkamen
          Article
          181446 Horm Res 1990;33:40–44
          10.1159/000181446
          2142930
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

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