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      Relative Bioavailability of Ethinyl Estradiol from Two Different Oral Contraceptive Formulations after Single Oral Administration to 18 Women in an Intraindividual Cross-Over Design

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          Two low-dose oral contraceptives, both containing the same dose of ethinyl estradiol (EE<sub>2</sub>) but different progestins (gestodene and desogestrel, respectively), were compared with respect to the relative bioavailability of EE<sub>2</sub>. After single-dose administration of both formulations to 18 women in an intraindividual cross-over design, there was no difference in the target variables for EE<sub>2</sub> (C<sub>max</sub>, t<sub>max</sub> and AUC). With respect to EE<sub>2</sub>, both formulations were bioequivalent. The observation of others, reporting higher EE<sub>2</sub> levels in the serum of women taking the gestodene-containing formulation as compared to those taking the desogestrel-containing formulation, was not confirmed.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 33
          : 1
          : 40-44
          Schering AG Research Laboratories, Berlin/Bergkamen
          181446 Horm Res 1990;33:40–44
          © 1990 S. Karger AG, Basel

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          Pages: 5
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