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      Anti-inflammatory Activity of the Invasive Neophyte Polygonum Cuspidatum Sieb. and Zucc. (Polygonaceae) and the Chemical Comparison of the Invasive and Native Varieties with regard to Resveratrol

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          Abstract

          Polygonum cuspidatum Sieb. and Zucc. has been traditionally used as a member of many anti-inflammatory polyherbal formulations, but is now a widespread invasive neophyte in Europe and America. To discuss if the invasive variety is chemically identical to the native one in traditional medicine, the different constituents of the invasive variety compared to the native variety were isolated and their anti-inflammatory activity was tested. Resveratroloside and catechin-(4α→8)-catechin, the newly found constituents in the invasive variety, have similar nitric oxide (NO) inhibition potency as that of piceid (the major constituent of P. cuspidatum), but the newly found major constituent, i.e., piceatannol glucoside, showed no apparent effect. On the other hand, as a marker, the total content of resveratrol in the methanol root extract after glucosidase hydrolysis was measured and compared between the invasive and native varieties. The total content of resveratrol measured in the root extracts of the Swiss sample was about 2.5 times less than that of the Chinese one. This study brings attention to the point that when the invasive variety of P. cuspidatum is used in traditional medicine, the chemical difference should be kept in mind.

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          Author and article information

          Journal
          J Tradit Complement Med
          J Tradit Complement Med
          JTCM
          Journal of Traditional and Complementary Medicine
          Medknow Publications & Media Pvt Ltd (India )
          2225-4110
          Jul-Sep 2013
          : 3
          : 3
          : 182-187
          Affiliations
          [1 ]Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
          [2 ]Shandong Qidu Pharmaceutical Co. Ltd, Zibo 255400, China
          [3 ]Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland
          Author notes
          Correspondence to: Dr. Tao Zhang, Shandong Qidu Pharmaceutical Co. Ltd, Zibo 255400, China. Tel: 0086 531 58673025, E-mail: hiversoleil@ 123456hotmail.com
          Article
          JTCM-3-182
          10.4103/2225-4110.114905
          3924989
          24716176
          Copyright: © Journal of Traditional and Complementary Medicine

          This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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          Original Research Paper

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