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      Serum Alpha-1-Acid Glycoprotein in Chronic Renal Failure

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          Abstract

          We measured the serum concentration of alpha-1-acid glycoprotein (AAG) in 30 healthy subjects (controls), in 54 patients with various degrees of residual renal function (group I), and in 98 patients in the terminal phase of chronic renal failure (CRF) on both conservative and dialytic therapy (group II). A positive correlation between the logarithm of serum AAG and serum creatinine levels was found in group I. Serum AAG increased significantly when serum creatinine rose above 10 mg/dl. This fact would indicate that a retention of the substance occurs as the renal function falls. The mean serum concentration of AAG was significantly higher in group II patients, with no difference between those on conservative therapy and those on maintenance hemodialysis. However, levels above normal were present in only a minority of cases. We conclude that the serum AAG measurement maintains its diagnostic value as an acute phase reactant also in the terminal phase of CRF.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1985
          1985
          04 December 2008
          : 39
          : 3
          : 160-163
          Affiliations
          aDivisione di Medicina, Servizio di Nefrologia e Dialisi (Prof. Enzo Pretolani); bLaboratorio di Analisi (Prof. Leonida Cenciotti), Ospedale M. Bufalini, Cesena; cIstituto di Nefrologia e Dialisi (Prof. Vittorio Bonomini), Policlinico Universitario S.Orsola, Bologna, Italia
          Article
          183364 Nephron 1985;39:160–163
          10.1159/000183364
          3919327
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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