Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma.

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Abstract

How hepatocellular carcinoma (HCC) cells acquire the ability to invade surrounding tissue is unknown, but epithelial mesenchymal transition (EMT) likely plays a role. We investigate how transforming growth factor (TGF)-beta1 and extracellular matrix protein Laminin-5 (Ln-5) induce EMT and cancer invasion.

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Journal

Journal ID (iso-abbrev): Gastroenterology

Title: Gastroenterology

Publisher: Elsevier BV

ISSN: 0016-5085

ISSN (Print): 0016-5085

Publication date (Electronic): Nov 2005

Volume: 129

Issue: 5

Affiliations

[1 ] Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy. g.giannelli@intmed.uniba.it

Article

Publisher Item ID: S0016-5085(05)01998-0

DOI: 10.1053/j.gastro.2005.09.055

PubMed ID: 16285938

SO-VID: 79783b50-9250-4d79-8183-86e82c723c57

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