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Two-component and phosphorelay signal transduction
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Abstract
Two-component and phosphorelay signal transduction systems are the major means by
which bacteria recognize and respond to a variety of environmental stimuli. Recent
results have implicated these systems in the regulation of a variety of essential
processes including cell-cycle progression, pathogenicity, and developmental pathways.
Elucidation of the structures of the interacting domains is leading to an understanding
of the mechanisms of molecular recognition and phosphotransfer in these systems.