+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Additive Effects of Atrial Natriuretic Peptide and Angiotensin II on Luteinizing Hormone and Prolactin Release in Female Rats


      S. Karger AG

      Atrial natriuretic peptide, Angiotensin II, Luteinizing hormone, Prolactin

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          The present experiments were designed to assess the effects of central administration of atrial natriuretic peptide (ANP), alone or in conjunction with angiotensin II (All), on luteinizing hormone (LH) and prolactin release in ovarian steroid-primed female rats. Intracerebroventricular injection of ANP (200 ng/2 µl over 1 min) induced an increase in plasma LH levels without significantly affecting prolactin release. Injection of All (50 ng/2 µl over 1 min) also resulted in an increase in LH levels and, in addition, reduced plasma prolactin titers. Coinjection of ANP and All did not elevate LH levels beyond that achieved by either peptide alone, but produced a further suppression in prolactin levels than that seen with All alone. Water intake induced by All was attenuated by coadministration of ANP. In a second protocol utilizing lower doses of the peptides delivered by infusion, either ANP (800 ng/h; 13.3 ng/min) or All (200 ng/h; 3.3 ng/min) alone produced 100% increases in LH levels. Coinfusion of the peptides induced an additive (250%) increase in plasma LH titers. In this protocol, the release of prolactin was unaffected by infusion of the peptides, either alone or as a comixture. Water intake induced by All infusion was attenuated by coadministration of ANP. Taken together, these experiments demonstrate that, in contrast to the antagonistic interaction of ANP and All on water intake, the peptides affect reproductive hormone secretion in the same direction and, under particular experimental conditions, display additive effects in stimulating LH and inhibiting prolactin release.

          Related collections

          Author and article information

          S. Karger AG
          03 April 2008
          : 51
          : 3
          : 345-350
          Department of Physiology, University of California, San Francisco, Calif., USA
          125359 Neuroendocrinology 1990;51:345–350
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Original Paper


          Comment on this article