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      Polyphenol and self-assembly: metal polyphenol nanonetwork for drug delivery and pharmaceutical applications

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          Most cited references25

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          Acidic extracellular microenvironment and cancer

          Yasumasa Kato, Shigeyuki Ozawa, Chihiro Miyamoto … (2013)
          Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being primarily considered to be due to lactate secretion from anaerobic glycolysis. Clinicopathological evidence shows that transporters and pumps contribute to H+ secretion, such as the Na+/H+ exchanger, the H+-lactate co-transporter, monocarboxylate transporters, and the proton pump (H+-ATPase); these may also be associated with tumor metastasis. An acidic extracellular pH not only activates secreted lysosomal enzymes that have an optimal pH in the acidic range, but induces the expression of certain genes of pro-metastatic factors through an intracellular signaling cascade that is different from hypoxia. In addition to lactate, CO2 from the pentose phosphate pathway is an alternative source of acidity, showing that hypoxia and extracellular acidity are, while being independent from each other, deeply associated with the cellular microenvironment. In this article, the importance of an acidic extracellular pH as a microenvironmental factor participating in tumor progression is reviewed.
          Article 0 comments Cited 386 times – based on 0 reviews     Review now
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            Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces

            Hirotaka Ejima, Frank Caruso, Joseph J Richardson (2017)
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              Metal Ion/Tannic Acid Assembly as a Versatile Photothermal Platform in Engineering Multimodal Nanotheranostics for Advanced Applications

              Wenlong Liu, Xianzheng Zhang, Xianlin Song … (2018)
              Article 0 comments Cited 122 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): FDD
                Title: Future Drug Discovery
                Abbreviated Title: Future Drug. Discov.
                Abbreviated Title: Future Drug Discovery
                Publisher: Newlands Press Ltd (London, UK )
                ISSN (Electronic): 2631-3316
                Publication date Collection: July 2019
                Publication date (Electronic): 12 April 2019
                Volume: 1
                Issue: 1
                Electronic Location Identifier: FDD7
                Affiliations
                [1] 1John A. Paulson School of Engineering & Applied Sciences, Harvard University, Cambridge, MA 02138, USA
                [2] 2Glanbia Nutritionals Inc., Twin Falls, ID 83301, USA
                [3] 3Department of Clinical Oncology, Longyan First Hospital Affiliated to Fujian Medical University, Longyan, China, 364000
                Author notes
                *Author for correspondence: xingcai@ 123456seas.harvard.edu
                Article
                DOI: 10.4155/fdd-2019-0001
                SO-VID: 7996c33f-5abf-44cd-a38c-8bedf2d78156
                Copyright © © 2019 Xingcai Zhang
                License:

                This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License

                History
                Date received : 01 January 2019
                Date accepted : 18 March 2019
                Date: 12 April 2019
                Categories
                Subject: Commentary

                ScienceOpen disciplines: Biochemistry,Molecular medicine,Pharmaceutical chemistry,Bioinformatics & Computational biology,Biotechnology,Pharmacology & Pharmaceutical medicine
                Keywords: anti-cancer,drug delivery,tea polyphenol,metal polyphenol nanonetworks (MPN),self-assembly,theranostics,bioavailability
                Data availability:
                ScienceOpen disciplines: Biochemistry, Molecular medicine, Pharmaceutical chemistry, Bioinformatics & Computational biology, Biotechnology, Pharmacology & Pharmaceutical medicine
                Keywords: anti-cancer, drug delivery, tea polyphenol, metal polyphenol nanonetworks (MPN), self-assembly, theranostics, bioavailability

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