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      A Study of Autoimmune Polyglandular Syndrome (APS) in Patients with Type1 Diabetes Mellitus (T1DM) Followed Up at a Teritiary Care Hospital.

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          Abstract

          Type1 diabetes mellitus (T1DM) results from auto- immune destruction of insulin-producing β cells and is characterized by the presence of insulitis and β-cell autoantibodies. Up to one third of patients develop an autoimmune polyglandular syndrome (APS). Presence of other autoimmune disorders in patients with T1DM has been associated with increased morbidity and mortality. Hypoglycemia resulting from concurrent hypothyroidism or adrenal crisis can be dangerous; starting replacement therapy for hypothyroidism may result in adrenal crisis if background hypocortisolism is not recognized. Early detection of antibodies and latent organ-specific dysfunction is advocated to alert physicians to take appropriate action in order to prevent full-blown disease.

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          Author and article information

          Journal
          J Clin Diagn Res
          Journal of clinical and diagnostic research : JCDR
          JCDR Research and Publications
          2249-782X
          0973-709X
          Feb 2014
          : 8
          : 2
          Affiliations
          [1 ] Assistant Professor, Department of Biochemistry, Institute of Medical Sciences and Research , Mayani, Maharashtra, India .
          [2 ] Assistant Professor, Department of Critical Care Medicine, St. John's Medical College , Bangalore, India .
          [3 ] Assistant Professor, Department of Biochemistry, DM Wayanad Institute of Medical Science , Meppadi, Naseera Nagar Kerala, India .
          Article
          10.7860/JCDR/2014/7013.4011
          3972603
          24701486
          79c01c3d-61eb-4558-95a2-beaca0b49349
          History

          Hypothyroidism,Addison’s disease,Autoantibodies,Autoimmune endocrinopathy,Autoimmune thyroid disease

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