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      Wiring optimization can relate neuronal structure and function

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      Proceedings of the National Academy of Sciences
      Proceedings of the National Academy of Sciences

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          Abstract

          We pursue the hypothesis that neuronal placement in animals minimizes wiring costs for given functional constraints, as specified by synaptic connectivity. Using a newly compiled version of the Caenorhabditis elegans wiring diagram, we solve for the optimal layout of 279 nonpharyngeal neurons. In the optimal layout, most neurons are located close to their actual positions, suggesting that wiring minimization is an important factor. Yet some neurons exhibit strong deviations from "optimal" position. We propose that biological factors relating to axonal guidance and command neuron functions contribute to these deviations. We capture these factors by proposing a modified wiring cost function.

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          Author and article information

          Journal
          Proceedings of the National Academy of Sciences
          Proceedings of the National Academy of Sciences
          Proceedings of the National Academy of Sciences
          0027-8424
          1091-6490
          March 21 2006
          March 21 2006
          March 14 2006
          March 21 2006
          : 103
          : 12
          : 4723-4728
          Article
          10.1073/pnas.0506806103
          1550972
          16537428
          79c14b32-4413-402a-932e-15d2e20670b8
          © 2006
          History

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