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      • Record: found
      • Abstract: found
      • Article: found

      Effect of Genetically Determined Host Factors on the Efficacy of Vidarabine, Acyclovir and 5-Trifluorothymidine in Herpes simplex Virus Type 1 Infection

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          Abstract

          The susceptibility of Herpes simplex virus (HSV) to acyclovir (ACV), 5-trifluorothymidine (TFT) and vidarabine (Ara-A) in HSV-infected embryo fibroblasts from BALB/c and C57BL/6 mice as well as Vero cells were measured. Ara-A and TFT (at its highest concentration) were more effective in Vero cells and BALB/c mouse embryo fibroblasts (MEF) than in C57BL/ 6 MEF. In contrast, ACV was more effective in C57BL/6 MEF than BALB/c MEF and Vero cells. These data suggest that genetically determined differences in the ability of host cells to support the replication of HSV influence the activity of antiviral drugs.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1994
          Publication date (Print): 1994
          Publication date (Electronic): 11 December 2009
          Volume: 26
          Issue: 2
          Pages: 95-104
          Affiliations
          aDepartment of Ophthalmology, and bDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Ga.; cMedical Research, Veterans Affairs Medical Center, Decatur, Ga.; dDepartment of Ophthalmology, School of Medicine Louisiana State University, New Orleans, La., USA
          Article
          Publisher ID: 267398 Other ID: Ophthalmic Res 1994;26:95–104
          DOI: 10.1159/000267398
          PubMed ID: 8196938
          SO-VID: 79c24a42-1122-4559-893d-ccfa8ed4d86c
          Copyright © © 1994 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 25 June 1993
          Date accepted : 12 August 1993
          Page count
          Pages: 10
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: In vitro HSV replication,Adenosine deaminase,Vidarabine,Virus,Mouse embryo fibroblast,Herpes simplex,Antiviral drugs,Acyclovir,5-Trifluorothymidine
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: In vitro HSV replication, Adenosine deaminase, Vidarabine, Virus, Mouse embryo fibroblast, Herpes simplex, Antiviral drugs, Acyclovir, 5-Trifluorothymidine

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