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      Effect of Genetically Determined Host Factors on the Efficacy of Vidarabine, Acyclovir and 5-Trifluorothymidine in Herpes simplex Virus Type 1 Infection

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          The susceptibility of Herpes simplex virus (HSV) to acyclovir (ACV), 5-trifluorothymidine (TFT) and vidarabine (Ara-A) in HSV-infected embryo fibroblasts from BALB/c and C57BL/6 mice as well as Vero cells were measured. Ara-A and TFT (at its highest concentration) were more effective in Vero cells and BALB/c mouse embryo fibroblasts (MEF) than in C57BL/ 6 MEF. In contrast, ACV was more effective in C57BL/6 MEF than BALB/c MEF and Vero cells. These data suggest that genetically determined differences in the ability of host cells to support the replication of HSV influence the activity of antiviral drugs.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          11 December 2009
          : 26
          : 2
          : 95-104
          aDepartment of Ophthalmology, and bDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Ga.; cMedical Research, Veterans Affairs Medical Center, Decatur, Ga.; dDepartment of Ophthalmology, School of Medicine Louisiana State University, New Orleans, La., USA
          267398 Ophthalmic Res 1994;26:95–104
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 10
          Original Paper


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