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      Diagnostic Accuracy of Cerebrospinal Fluid Amyloid-β Isoforms for Early and Differential Dementia Diagnosis.

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          Abstract

          Overlapping cerebrospinal fluid biomarkers (CSF) levels between Alzheimer's disease (AD) and non-AD patients decrease differential diagnostic accuracy of the AD core CSF biomarkers. Amyloid-β (Aβ) isoforms might improve the AD versus non-AD differential diagnosis.

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          Author and article information

          Journal
          J. Alzheimers Dis.
          Journal of Alzheimer's disease : JAD
          1875-8908
          1387-2877
          2015
          : 45
          : 3
          Affiliations
          [1 ] Reference Center for Biological Markers of Dementia (BIODEM), and Biobank, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
          [2 ] Janssen Research and Development, Neuroscience Discovery, Beerse, Belgium.
          [3 ] Janssen Research and Development, Experimental Medicine Neuroscience, Beerse, Belgium.
          [4 ] StatUa Center for Statistics, University of Antwerp, Antwerp, Belgium.
          [5 ] Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
          [6 ] Reference Center for Biological Markers of Dementia (BIODEM), and Biobank, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen (UMCG), Groningen, The Netherlands.
          [7 ] Reference Center for Biological Markers of Dementia (BIODEM), and Biobank, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium.
          Article
          V4508K6H30T16287
          10.3233/JAD-141986
          25633670
          79e26cf1-3821-4e61-8f8c-e3cdd329c4ef
          History

          Alzheimer's disease,amyloid,biological markers,cerebrospinal fluid,diagnosis,differential,mild cognitive impairment

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