+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Plasma Melatonin Rhythm in Disorders of Puberty: Interactions of Age and Pubertal Stages

      Hormone Research in Paediatrics

      S. Karger AG

      Melatonin, Delayed puberty, Precocious puberty

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          A concurrent effect of age and puberty has hampered assessment of the influence of melatonin on human puberty. This study examined the pineal-puberty interaction in 41 subjects (ages 5–17 years) whose puberty was asynchronous from age (constitutional delay, hypopituitarism and idiopathic precocious puberty). Melatonin nocturnal profile was determined using blood samples drawn hourly by constant withdrawal. There was no significant trend for melatonin peak or time peak in pubertal or age groups. The linear correlation between age and melatonin peak was not significant. Thus, neither age nor puberty alone can account for the decline in nocturnal melatonin concentration observed across human development.

          Related collections

          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 36
          : 1-2
          : 16-21
          Department of Pediatrics, Brown University, East Providence, R.I., USA
          182099 Horm Res 1991;36:16–21
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Original Paper


          Comment on this article